The literature review examined associations between diagnosis, treatment and outcomes in D/EE-SWAS.
Across 34 studies, study designs were inconsistent, including differing inclusion criteria and outcome measures.
Reduction in spike-wave index (SWI), variably defined, and/or seizure frequency were the most commonly reported outcomes.
Reduced SWI or seizure frequency did not consistently correlate with cognitive improvement.
Although seizure frequency and severity often improve over time for children with D/EE-SWAS who have seizures, long-term cognitive deficits can be substantial and may prevent independent living for many.
Delayed treatment has been associated with poorer outcomes, making early recognition and treatment important.
There is no clear consensus on the optimal treatment for children with D/EE-SWAS.
Consequently, clinicians often make treatment decisions using limited evidence, anecdotal reports and individual clinical experience.
Well-controlled, high-quality studies are needed to develop evidence-based treatment guidelines and support earlier, more effective intervention.
Read the article: https://www.sciencedirect.com/science/article/abs/pii/S0920121106002038